Intraperitoneal bupivacaine does not attenuate pain following laparoscopic cholecystectomy.

O. Zmora, O. Stolik-Dollberg, B. Bar-Zakai, D. Rosin, J. Kuriansky, M. Shabtai, A. Perel, A. Ayalon

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Laparoscopic cholecystectomy is characterized by a short hospital stay. Hence, pain control on the day of surgery is increasingly important. The aim of this study was to evaluate the effect of intraperitoneal bupivacaine on pain relief following laparoscopic cholecystectomy. METHODS: Sixty patients undergoing elective laparoscopic cholecystectomy were prospectively randomized into 2 groups. Following removal of the gallbladder, group A received 100 mg of bupivacaine in 50 cc of saline, installed into the gallbladder bed and right subphrenic space. Group B received saline without bupivacaine. Pain was assessed using a visual/analog scale at fixed-time intervals. RESULTS: No significant difference occurred in the average pain levels between the groups at 1, 2, 4, and 14 hours postsurgery. The average analgesic requirement was lower in the bupivacaine group, but this did not reach statistical significance. CONCLUSION: Application of intraperitoneal bupivacaine did not attenuate pain following laparoscopic cholecystectomy, and no role exists for its routine use.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalJournal of the Society of Laparoendoscopic Surgeons
Issue number4
StatePublished - 2000


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