Intraoperative US of the pituitary gland work in progress

John L. Doppman*, Zvi Ram, Thomas H. Shawker, Edward H. Oldfield

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


PURPOSE: To evaluate the use of ultrasound (US) of the pituitary gland during transsphenoidal surgery as a means of detecting microadenomas in patients with Gushing disease. MATERIALS AND METHODS: Thirteen patients with Gushing disease and one with acromegaly underwent US during transsphenoidal surgery. Mechanically oscillating transducers (10 MHz [n = 8] or 15 MHz [n = 6]) mounted on a 15-cm-long probe were used. RESULTS: Seven adenomas were definitely visualized, two were poorly seen, and four were overlooked. Small tumors (<5 mm in diameter) tended to be hypoechoic; larger ones, hyperechoic. All four overlooked adenomas were imaged with the 15-MHz transducer. The cavernous sinuses and internal carotid arteries could be seen, but minimal invasion of the medial wall of the cavernous sinus could not. CONCLUSION: Pituitary microadenomas can be detected with transsphenoidal US; however, evaluation of larger series with instrumentation developed specifically for transsphenoidal application will be necessary to determine the ultimate value of this technique.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
Issue number1
StatePublished - Jul 1994
Externally publishedYes


  • Acromegaly, 145.512
  • Gushing syndrome, 145.54
  • Pituitary, neoplasms, 145.372
  • Ultrasound (US), intraoperative, 145.12982


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