Intramyocardial angiogenic cell precursors in nonischemic dilated cardiomyopathy

Kitipan V. Arom, Permyos Ruengsakulrach, Michael Belkin, Montip Tiensuwan

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the efficacy of intramyocardial injection of angiogenic cell precursors in nonischemic dilated cardiomyopathy, 35 patients with nonischemic dilated cardiomyopathy underwent injections of angiogenic cell precursors into the left ventricle (cell group). Seventeen patients with nonischemic dilated cardiomyopathy were matched from the heart failure database to form a control group that was treated medically. Angiogenic cell precursors were obtained from autologous blood, cultured in vitro, and injected into all free-wall areas of the left ventricle in the cell group. After these injections, New York Heart Association functional class improved significantly by 1.1 ± 0.7 classes at 284.7 ± 136.2 days, and left ventricular ejection fraction improved in 71.4% of patients (25/35); the mean increase in left ventricular ejection fraction was 4.4% ± 10.6% at 192.7 ± 135.1 days. Improved quality of life was demonstrated by better physical function, role-physical, general health, and vitality domains in a short-form health survey at the 3-month follow-up. In the control group, there were no significant improvements in left ventricular ejection fraction or New York Heart Association class which increased by 0.6 ± 0.8 classes. It was concluded that intramyocardial angiogenic cell precursor injection is probably effective in the treatment of nonischemic dilated cardiomyopathy. Disclosures and Freedom of Investigation Professor Michael Belkin is an advisory board member, a minor shareholder, and receives a consulting fee from TheraVitae Co. Ltd. However, the authors had full control of the study, methods used, outcome measurements, data analysis, and production of the written report.

Original languageEnglish
Pages (from-to)382-388
Number of pages7
JournalAsian Cardiovascular and Thoracic Annals
Volume17
Issue number4
DOIs
StatePublished - 2009

Keywords

  • Adult stem cells
  • Cardiomyopathy
  • Dilated
  • Heart failure
  • Hematopoietic stem cell transplantation
  • Left
  • Ventricular dysfunction

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