Intramitochondrial crystalline inclusions in the liver of a patient with hyperthyroidism

E. M. Mandel, P. Fishman, E. Kissin, L. Har-Zaav, M. Djaldetti

Research output: Contribution to journalArticlepeer-review


The case of a female patient of 60 with hyperthyroidism and slightly impaired liver function is described. Histologic examination of liver biopsy did not reveal any pathologic findings. Electron microscopic examination revealed crystalline inclusions in a great number of the mitochondria of the liver cells, as well as increased size of the mitochondria. Similar findings were obtained upon examination of a liver biopsy performed 6 mth after start of treatment for hyperthyroidism. Examination of the skin, muscle and white blood cells did not show the presence of such inclusions in the mitochondria. The significance of these findings in the liver cells is discussed.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalActa Hepato-Gastroenterologica
Issue number3
StatePublished - 1976


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