TY - JOUR
T1 - Intradermal sex hormone desensitization for relief of premenstrual symptoms may improve the obstetric outcome of women with recurrent pregnancy loss
AU - Itsekson, Alek M.
AU - Soriano, David
AU - Zolti, Mattityahu
AU - Seidman, Daniel S.
AU - Carp, Howard J.A.
N1 - Funding Information:
The results of subsequent live births were compared to those previously reported in our population of women with RPL [12] and that of others [13] in the literature. This study was supported by a grant from the Israel Ministry of Health. Institutional Review Board Approval was obtained for this study. All clinical and laboratory tests and other diagnostic procedures were in accordance with the ethical standards of the institutional and national committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 1983 and Good Clinical Practice.
PY - 2013/2
Y1 - 2013/2
N2 - The aim of this study was to determine whether women with recurrent pregnancy loss (RPL) and concurrent premenstrual syndrome (PMS) who underwent desensitization with sex hormones had an improved obstetric outcome. This manuscript summarizes a 10 year open label prospective follow up study of 26 women with RPL, aged 25-42 with 3-8 previous miscarriages and PMS, who had hormone hypersensitivity on skin testing. Skin testing was positive to estradiol in 23 women, progesterone in 20 women and to both estrogen and progesterone in 17 women. Amelioration of the symptoms of PMS (according to the VAS) was seen in 21 of 26 patients after desensitization with small doses of sex hormones intradermally. There was long term and stable reduction of severe PMS in 21 of 26 patients after desensitization. Five women conceived after skin testing, prior to desensitization. Sixteen of 26 women (61%) had subsequent live births. Five women had two subsequent live births in the subsequent pregnancy. There were no obstetric complications. Five women had two subsequent pregnancies with live births. It seems that correction of sex hormone hypersensitivity was accompanied by relief of persistent PMS, may have a positive effect on the chances of a successful pregnancy.
AB - The aim of this study was to determine whether women with recurrent pregnancy loss (RPL) and concurrent premenstrual syndrome (PMS) who underwent desensitization with sex hormones had an improved obstetric outcome. This manuscript summarizes a 10 year open label prospective follow up study of 26 women with RPL, aged 25-42 with 3-8 previous miscarriages and PMS, who had hormone hypersensitivity on skin testing. Skin testing was positive to estradiol in 23 women, progesterone in 20 women and to both estrogen and progesterone in 17 women. Amelioration of the symptoms of PMS (according to the VAS) was seen in 21 of 26 patients after desensitization with small doses of sex hormones intradermally. There was long term and stable reduction of severe PMS in 21 of 26 patients after desensitization. Five women conceived after skin testing, prior to desensitization. Sixteen of 26 women (61%) had subsequent live births. Five women had two subsequent live births in the subsequent pregnancy. There were no obstetric complications. Five women had two subsequent pregnancies with live births. It seems that correction of sex hormone hypersensitivity was accompanied by relief of persistent PMS, may have a positive effect on the chances of a successful pregnancy.
KW - Hormone hypersensitivity
KW - Preconceptual desensitization
KW - Premenstrual syndrome
KW - Recurrent pregnancy loss
UR - http://www.scopus.com/inward/record.url?scp=84871441756&partnerID=8YFLogxK
U2 - 10.3109/09513590.2012.730582
DO - 10.3109/09513590.2012.730582
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AN - SCOPUS:84871441756
SN - 0951-3590
VL - 29
SP - 169
EP - 172
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 2
ER -
