Intracerebral hemorrhage after IV rt-PA therapy for acute ischemic stroke

David Tanne*, Scott E. Kasner, Andrew M. Demchuk, Steven R. Levine

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We evaluated data from 1,205 patients treated with intravenous recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke within 3 hours of symptom onset to identify pretreatment predictors of rt-PA-related intracerebral hemorrhage. Our findings suggest stroke severity, diabetes mellitus, increasing serum glucose, early ischemic changes on computed tomography, and decreasing platelet counts are associated with thrombolysis-related intracerebral hemorrhage. These risk factors may help physicians identify patients at high and low risk for rt-PA treatment and better understand the pathophysiology of thrombosis-related intracerebral hemorrhage.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalCardiology Review
Issue number12
StatePublished - Oct 2002
Externally publishedYes


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