Intracavernosal saline infusion decreases intraoperative blood loss during radical retropubic prostatectomy

Kobi Stav, Fanus Zacci, Murat Bahar, Dan Leibovici, Arie Lindner, Amnon Zisman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: Radical retropubic prostatectomy (RRP) is associated with intraoperative blood loss. We studied whether regional hemodilution using intracavernosal saline infusion has an impact on blood loss during RRP. Methods: This is a prospective, randomized controlled study. There were 16 patients treated with intracavernosal saline infusion, and 17 did not receive infusion and served as the control group. Patients who received neoadjuvant therapy and those who underwent pelvic lymph node dissection or salvage RRP were excluded. Both corpora were infused in a pressure of 80-cm water. Clinical, pathologic, and laboratory parameters were evaluated and compared. Intraoperative actual blood loss was calculated. Results: Blood loss was significantly higher in the control group (1,036 ± 176 vs. 482 ± 184 ml; P < 0.001). Postoperatively, 3 control patients received 2 packed-cell units each. There were no differences between the 2 groups in regard to patient's age, comorbidities, body mass index, American Society of Anesthesiologists score, prostate-specific antigen level, clinical or pathologic stage, Gleason score, prostate specimen weight, and operating time. Localized penile edema developed in 6 patients (37.5%) that resolved spontaneously 48 hours postoperatively. None of the patients had symptoms or signs of systemic fluid overload. Conclusion: Our result indicates that localized hemodilution using intracavernosal saline infusion is feasible, safe, and significantly decreases blood loss during RRP.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalUrologic Oncology: Seminars and Original Investigations
Issue number2
StatePublished - Mar 2008


  • Blood loss
  • Dilution
  • Infusion
  • Prostate
  • Prostatectomy


Dive into the research topics of 'Intracavernosal saline infusion decreases intraoperative blood loss during radical retropubic prostatectomy'. Together they form a unique fingerprint.

Cite this