TY - JOUR
T1 - Intracardiac echocardiography
T2 - In vitro and in vivo validation for right ventricular volume and function
AU - Vazquez De Prada, Jose A.
AU - Chen, Ming Hui
AU - Guerrero, J. Luis
AU - Padial, Luis R.
AU - Jiang, Leng
AU - Schwammenthal, Ehud
AU - Sagie, Alik
AU - Weyman, Arthur E.
AU - Levine, Robert A.
AU - Chen, Chunguang
N1 - Funding Information:
From the aCardiac Ultrasound Laboratory, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, and the bDi-vision of Cardiology, Hartford Hospital, the University of Connecticut School of Medicine, Hartford. Dr. Vazquez de Prada and Dr. R. Padial supported by research awards from Fondo de Investigacion Sanitaria (Spanish Ministry of Health). Dr. Levine is an Established Investigator of the American Heart Association, Dallas, Texas. Dr. Chunguang Chen supported in part by Beatrice Fox Auerbach Foundation and Hartford Hospital Research Fund. Received for publication Feb. 2, 1995; accepted June 19, 1995. Reprint requests: Chunguang Chert, MD, Division of Cardiology, Hartford Hospital, 80 Seymour St., Hartford, CT 06102. Copyright © 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + 0 4/1/68057
PY - 1996
Y1 - 1996
N2 - To determine the feasibility and accuracy of intracardiac ultrasonography (ICUS) for the measurement of right ventricular (RV) volumes and function, a 10 MHz ICUS catheter was used in an in vitro and in vivo model. In the in vitro study, 16 sheep hearts were imaged. Sequential cross-sectional images from RV apex to base were recorded during a calibrated pullback. Volumes were calculated by applying Simpson's algorithm. ICUS-obtained volumes correlated well with actual volumes (standard error of estimate [SEE] = 2.3 ml, r = 0.98). For the in vivo study, a beating-heart canine model was used (31 hemodynamic stages in six dogs). Actual volumes were measured by an intracavitary balloon connected to an external column. Sequential cross- sectional images were recorded during the ICUS catheter pullback from apex to base of the RV, and volumes calculated by Simpson's algorithm. Good correlations were observed between ICUS and actual values for diastolic (SEE = 4.1 ml, r= 0.97), systolic (SEE=3.4 ml, r=0.96), and ejection fraction (SEE = 3.1%, r = 0.87) values. This new technique can accurately quantitate RV volumes, can function both in vitro and in vivo, and has the potential for increasing applications to questions of clinical and research interest.
AB - To determine the feasibility and accuracy of intracardiac ultrasonography (ICUS) for the measurement of right ventricular (RV) volumes and function, a 10 MHz ICUS catheter was used in an in vitro and in vivo model. In the in vitro study, 16 sheep hearts were imaged. Sequential cross-sectional images from RV apex to base were recorded during a calibrated pullback. Volumes were calculated by applying Simpson's algorithm. ICUS-obtained volumes correlated well with actual volumes (standard error of estimate [SEE] = 2.3 ml, r = 0.98). For the in vivo study, a beating-heart canine model was used (31 hemodynamic stages in six dogs). Actual volumes were measured by an intracavitary balloon connected to an external column. Sequential cross- sectional images were recorded during the ICUS catheter pullback from apex to base of the RV, and volumes calculated by Simpson's algorithm. Good correlations were observed between ICUS and actual values for diastolic (SEE = 4.1 ml, r= 0.97), systolic (SEE=3.4 ml, r=0.96), and ejection fraction (SEE = 3.1%, r = 0.87) values. This new technique can accurately quantitate RV volumes, can function both in vitro and in vivo, and has the potential for increasing applications to questions of clinical and research interest.
UR - http://www.scopus.com/inward/record.url?scp=13344279413&partnerID=8YFLogxK
U2 - 10.1016/S0002-8703(96)90361-0
DO - 10.1016/S0002-8703(96)90361-0
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C2 - 8579028
AN - SCOPUS:13344279413
SN - 0002-8703
VL - 131
SP - 320
EP - 328
JO - American Heart Journal
JF - American Heart Journal
IS - 2
ER -