Intraamniotic prostaglandin F2α for pregnancy termination in the second and early third trimesters of pregnancy

Shlomo Lipitz, Dan Grisaru, Alexander Libshiz, Zeev Rotstein, Eyal Schiff, Arie Lidor, Reuwen Achiron

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To examine the effectiveness and safety of intraamniotic prostaglandin F2α (PGF2α) instillation during second- and early third- trimester termination of pregnancy.STUDY DESIGN: The study group consisted of 173 women between 18 and 32 weeks of gestation admitted for termination of pregnancy with a live, singleton fetus. The procedure included intraamniotic instillation of 40 mg PGF2α. In cases of failed induction, after 24 hours an additional procedure (repeat ed PGF2α injection, oxytocin augmentation or extraovular balloon installation) was performed. RESULTS: The mean induction-to-abortion interval was 27±17 hours, 26 minutes. The induction-to-abortion interval was not significantly influenced by parity, maternal age, indication for pregnancy termination or gestational age at the time of the procedure. Complications were related to a longer induction-to- abortion interval (35 hours, 41 minutes±26 hours, 15 minutes in complicated cases as compared to 25 hours, 43 minutes ± 15 hours, 28 minutes, P = .012). However, complications were uncommon. CONCLUSION: Intraamniotic PGF2α instillation was safely used for termination of pregnancy, even at advanced gestational ages. The induction-to-abortion interval is the main factor influencing complications and is important as a catalyst for cases that fail to abort within 24 hours.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalThe Journal of reproductive medicine
Issue number4
StatePublished - Apr 1997
Externally publishedYes


  • abortion, therapeutic
  • prostaglandin F2alpha


Dive into the research topics of 'Intraamniotic prostaglandin F2α for pregnancy termination in the second and early third trimesters of pregnancy'. Together they form a unique fingerprint.

Cite this