Intra-arterial thrombolytic therapy: A combined approach with angioplasty and/or minor surgery

B. Morag, A. Garniek, A. Setton, J. Schneiderman, R. Walden, Z. Rubinstein

Research output: Contribution to journalArticlepeer-review

Abstract

Low-dose intra-arterial treatment was performed in 124 patients who underwent a total of 142 procedures. The series included 87 occluded arteries and 55 occluded grafts. In only 29 instances (21%) was thrombolysis alone sufficient. In another 77 procedures (54%) the thrombolysis was followed by either angioplasty or minor surgery. In the remaining 36 treatments (25%) lysis of the occlusion failed. A successful end result of combined treatment was achieved in 67 of 77 (87%) procedures. Including the 29 patients in whom thrombolysis alone sufficed, a total of 96 of the 142 procedures (67%) were successful, with the overall success rate being better in grafts (78%) than in arteries (61%). The suprainguinal lesions had a significantly better response compared to the infra-inguinal ones. The evaluation of all procedures was done at the time of discharge from hospital. Complications were related either to local or systemic hemorrhage or distal embolization. Death related to treatment occurred in three patients.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalIsrael Journal of Medical Sciences
Volume29
Issue number11
StatePublished - 1993
Externally publishedYes

Keywords

  • Angioplasty
  • Arteries
  • Grafts
  • Streptokinase
  • Thrombolytic therapy
  • Urokinase

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