Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy

Kathleen Lee-Sarwar; Rachel S. Kelly; Jessica Lasky-Su; D. Branch Moody; Alex R. Mola; Tan Yun Cheng; Laurie E. Comstock; Robert S. Zeiger; George T. O'Connor; Megan T. Sandel; Leonard B. Bacharier; Avraham Beigelman; Nancy Laranjo; Diane R. Gold; Supinda Bunyavanich; Jessica H. Savage; Scott T. Weiss; Patrick J. Brennan; Augusto A. Litonjua

doi:10.1016/j.jaci.2018.04.016

Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy

Kathleen Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, D. Branch Moody, Alex R. Mola, Tan Yun Cheng, Laurie E. Comstock, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Supinda Bunyavanich, Jessica H. Savage, Scott T. Weiss, Patrick J. Brennan, Augusto A. Litonjua

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Original language	English
Pages (from-to)	335-338.e9
Journal	Journal of Allergy and Clinical Immunology
Volume	142
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2018.04.016
State	Published - Jul 2018
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health	AI102945, R01AI118833, 5T32AI007306-30, R01AR048632
National Heart, Lung, and Blood Institute	R01HL108818, R01HL091528

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10.1016/j.jaci.2018.04.016

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Lee-Sarwar, K., Kelly, R. S., Lasky-Su, J., Moody, D. B., Mola, A. R., Cheng, T. Y., Comstock, L. E., Zeiger, R. S., O'Connor, G. T., Sandel, M. T., Bacharier, L. B., Beigelman, A., Laranjo, N., Gold, D. R., Bunyavanich, S., Savage, J. H., Weiss, S. T., Brennan, P. J., & Litonjua, A. A. (2018). Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy. Journal of Allergy and Clinical Immunology, 142(1), 335-338.e9. https://doi.org/10.1016/j.jaci.2018.04.016

@article{27aebb9f71d44fc6b26744529b78d9a6,

title = "Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy",

author = "Kathleen Lee-Sarwar and Kelly, {Rachel S.} and Jessica Lasky-Su and Moody, {D. Branch} and Mola, {Alex R.} and Cheng, {Tan Yun} and Comstock, {Laurie E.} and Zeiger, {Robert S.} and O'Connor, {George T.} and Sandel, {Megan T.} and Bacharier, {Leonard B.} and Avraham Beigelman and Nancy Laranjo and Gold, {Diane R.} and Supinda Bunyavanich and Savage, {Jessica H.} and Weiss, {Scott T.} and Brennan, {Patrick J.} and Litonjua, {Augusto A.}",

note = "Funding Information: Disclosure of potential conflict of interest: J. Lasky-Su is a consultant to Metabolon Inc. R. S. Zeiger participates on the Scientific Advisory Board of DBV Technologies, receives stock from DBV Technologies, and participates on the Data Safety Monitoring Committee of AIMMUNE. G. T. O'Connor is a coinvestigator on a grant from Janssen Pharmaceuticals to Boston University that funds a study of the pathogenesis of chronic obstructive pulmonary disease. L. B. Bacharier participates on the Data Safety Monitoring Board of DBV Technologies. A. Beigelman holds stock from DBV Technologies. S. Bunyavanich receives funding from the National Institutes of Health (grant no. R01AI118833). J. H. Savage is currently employed by Vertex Pharmaceuticals and has unvested stock in Vertex Pharmaceuticals, and her husband is employed by Shire and has unvested stock in Shire. S. T. Weiss is a paid consultant to UpToDate. A. A. Litonjua is a consultant to AstraZeneca, LP. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: The Vitamin D Antenatal Asthma Reduction Trial was funded by the National Heart, Lung, and Blood Institute (grant no. U01HL091528). Additional funding came from the National Institutes of Health (NIH) (grant nos. R01HL108818 and 5T32AI007306-30). P.J.B. was supported by the NIH (grant no. AI102945) and generous support from the Goodfellow, Violin, and Karol families. P.J.B. and L.E.C. were supported by the Brigham and Women's Hospital Innovation Evergreen Fund. T.-Y.C. and D.B.M. were supported by the NIH (grant no. R01AR048632). ",

year = "2018",

month = jul,

doi = "10.1016/j.jaci.2018.04.016",

language = "אנגלית",

volume = "142",

pages = "335--338.e9",

journal = "Journal of Allergy and Clinical Immunology",

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Lee-Sarwar, K, Kelly, RS, Lasky-Su, J, Moody, DB, Mola, AR, Cheng, TY, Comstock, LE, Zeiger, RS, O'Connor, GT, Sandel, MT, Bacharier, LB, Beigelman, A, Laranjo, N, Gold, DR, Bunyavanich, S, Savage, JH, Weiss, ST, Brennan, PJ & Litonjua, AA 2018, 'Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy', Journal of Allergy and Clinical Immunology, vol. 142, no. 1, pp. 335-338.e9. https://doi.org/10.1016/j.jaci.2018.04.016

TY - JOUR

T1 - Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy

AU - Lee-Sarwar, Kathleen

AU - Kelly, Rachel S.

AU - Lasky-Su, Jessica

AU - Moody, D. Branch

AU - Mola, Alex R.

AU - Cheng, Tan Yun

AU - Comstock, Laurie E.

AU - Zeiger, Robert S.

AU - O'Connor, George T.

AU - Sandel, Megan T.

AU - Bacharier, Leonard B.

AU - Beigelman, Avraham

AU - Laranjo, Nancy

AU - Gold, Diane R.

AU - Bunyavanich, Supinda

AU - Savage, Jessica H.

AU - Weiss, Scott T.

AU - Brennan, Patrick J.

AU - Litonjua, Augusto A.

N1 - Funding Information: Disclosure of potential conflict of interest: J. Lasky-Su is a consultant to Metabolon Inc. R. S. Zeiger participates on the Scientific Advisory Board of DBV Technologies, receives stock from DBV Technologies, and participates on the Data Safety Monitoring Committee of AIMMUNE. G. T. O'Connor is a coinvestigator on a grant from Janssen Pharmaceuticals to Boston University that funds a study of the pathogenesis of chronic obstructive pulmonary disease. L. B. Bacharier participates on the Data Safety Monitoring Board of DBV Technologies. A. Beigelman holds stock from DBV Technologies. S. Bunyavanich receives funding from the National Institutes of Health (grant no. R01AI118833). J. H. Savage is currently employed by Vertex Pharmaceuticals and has unvested stock in Vertex Pharmaceuticals, and her husband is employed by Shire and has unvested stock in Shire. S. T. Weiss is a paid consultant to UpToDate. A. A. Litonjua is a consultant to AstraZeneca, LP. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: The Vitamin D Antenatal Asthma Reduction Trial was funded by the National Heart, Lung, and Blood Institute (grant no. U01HL091528). Additional funding came from the National Institutes of Health (NIH) (grant nos. R01HL108818 and 5T32AI007306-30). P.J.B. was supported by the NIH (grant no. AI102945) and generous support from the Goodfellow, Violin, and Karol families. P.J.B. and L.E.C. were supported by the Brigham and Women's Hospital Innovation Evergreen Fund. T.-Y.C. and D.B.M. were supported by the NIH (grant no. R01AR048632).

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AN - SCOPUS:85047617124

SN - 0091-6749

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SP - 335-338.e9

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 1

ER -

Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy

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