Intestinal macrophages: Well educated exceptions from the rule

Ehud Zigmond, Steffen Jung

Research output: Contribution to journalReview articlepeer-review

Abstract

Macrophages are the most abundant mononuclear phagocytes in the healthy intestinal lamina propria and have emerged as crucial sentinels for the maintenance of tissue homeostasis. Matching the dynamic mucosal landscape, CX3C chemokine receptor (CX3CR)1-expressing macrophages are relatively short lived, and as opposed to most other tissue macrophages, are continuously replaced from blood monocytes that acquire in the healthy tissue context a robust noninflammatory gene expression signature. By contrast, during gut inflammation, monocytes differentiate in the gut into proinflammatory effector cells, as well as migratory antigen-presenting cells. Manipulation of monocyte fates in the intestine might hold promise for the disease management of inflammatory bowel disorders.

Original languageEnglish
Pages (from-to)162-168
Number of pages7
JournalTrends in Immunology
Volume34
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Keywords

  • Inflammatory bowel disorder
  • Intestine
  • Macrophages
  • Monocytes

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