Intestinal elimination of ciprofloxacin in rabbits

J. Ramon, S. Dautrey, R. Farinoti, C. Carbon, E. Rubinstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The intestinal transepithelial elimination of ciprofloxacin was studied in a rabbit model. Jejunal, ileal, and cecal segments along with their intact blood vessels were isolated and perfused, and their contents were collected over a 120-min period following administration of a single parenteral dose of 27 mg of ciprofloxacin per kg of body weight. The intestinal elimination rates of ciprofloxacin were 0.126 ± 0.084, 0.235 ± 0.22, and 0.11 ± 0.084 μg · min-1 · cm-2 for the jejunal, ileal, and cecal segments, respectively. The calculated fractions of ciprofloxacin eliminated were 3.3 mg from the jejunum and 13.8 mg from the ileum, representing 19% of the administered dose. Additional amounts of 2.5 to 3.7 mg or 4.9 to 7.3% of the administered dose were eliminated from the cecum. Elimination was probably not due to a passive diffusion process but rather due to an active transepithelial transport. This intestinal elimination pattern of ciprofloxacin may explain the unusual activity of the fluoroquinolones in modifying the intestinal flora.

Original languageEnglish
Pages (from-to)757-760
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number4
StatePublished - 1994
Externally publishedYes


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