Interstitial Fluid Concentrations of Cefsulodin, Azlocillin and Carbenicillin

Zvi Landau, Hillel Halkin, Ethan Rubinstein

Research output: Contribution to journalArticlepeer-review


Cefsulodin, azlocillin and carbenicillin were administered by intramuscular injection to rats in a dose of 100 mg/kg. The serum concentration in frequent samples after administration was determined and compared with the interstitial fluid (IF) concentration, measured with implanted paper discs enveloped in a dialysis tube. The IF concentration of cefsulodin was significantly higher than that of the other two antibiotics. The AUC in the IF was also larger for cefsulodin.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Issue number3
StatePublished - Sep 1981


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