Interrelationships among anxiety, aggression, impulsivity, and mood: A serotonergically linked cluster?

Alan Apter, Herman M. van Praag, Robert Plutchik, Serge Sevy, Martin Korn, Serena Lynn Brown

Research output: Contribution to journalArticlepeer-review


Serotonin abnormalities appear to be related to a variety of psychopathological dimensions such as anxiety, depressed mood, impulsivity, and aggression dysregulation. We hypothesized that the psychopathological dimensions related to serotonin would be significantly intercorrelated since they seem to have a common biological basis. Sixty psychiatric inpatients were examined on a series of psychometric tests measuring suicidality, violence potential, impulsivity, depressive mood, and anxiety. The scores on all of these measures tended to be significantly correlated with one another. These findings support the additional hypothesis that biological markers may be more closely related to basic psychological dimensions than to nosological categories.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalPsychiatry Research
Issue number2
StatePublished - May 1990
Externally publishedYes


  • Serotonin
  • depression
  • psychiatric inpatients
  • psychometric tests
  • suicidality
  • violence


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