@article{2134966946334c3896d15d17f4e8882c,
title = "Interpreting clone-mediated perturbations of morphogen profiles",
abstract = "Generating clones of mutated cells within a wild-type tissue is a powerful experimental paradigm for elucidating gene function. Recently, this approach was employed for identifying genes that shape morphogen profiles in the Drosophila wing-imaginal disc. Interpreting such experiments poses a theoretical challenge. We present a general framework that links specific features of the morphogen profile in the clone vicinity to three basic morphogen properties: diffusion, degradation, and binding to immobile elements. Our results provide rigorous criteria to examine existing data and can facilitate the design and interpretation of future clone experiments.",
keywords = "Clonal analysis, Drosophila, Modeling, Morphogen",
author = "Avigdor Eldar and Naama Barkai",
note = "Funding Information: We thank Benny Shilo for discussion and comments on the manuscript. This work was supported by the Minerva and by the ISF. N.B. is the incumbent of the Soretta and Henry Shapiro career development chair. ",
year = "2005",
month = feb,
day = "1",
doi = "10.1016/j.ydbio.2004.11.002",
language = "אנגלית",
volume = "278",
pages = "203--207",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Elsevier Inc.",
number = "1",
}