Interpreting clone-mediated perturbations of morphogen profiles

Avigdor Eldar, Naama Barkai

Research output: Contribution to journalArticlepeer-review


Generating clones of mutated cells within a wild-type tissue is a powerful experimental paradigm for elucidating gene function. Recently, this approach was employed for identifying genes that shape morphogen profiles in the Drosophila wing-imaginal disc. Interpreting such experiments poses a theoretical challenge. We present a general framework that links specific features of the morphogen profile in the clone vicinity to three basic morphogen properties: diffusion, degradation, and binding to immobile elements. Our results provide rigorous criteria to examine existing data and can facilitate the design and interpretation of future clone experiments.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalDevelopmental Biology
Issue number1
StatePublished - 1 Feb 2005
Externally publishedYes


  • Clonal analysis
  • Drosophila
  • Modeling
  • Morphogen


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