Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction

Gabriel I. Barbash; Hanoch Hod; Shemuel Rath; Hilton I. Miller; Arie Roth; Yedahel Har-Zahav; Michaela Modan; Zeev Rotstein; Alex Batler; Ariela Zivelin; Joseph Charnilass; Elieser Kaplinsky; Shlomo Laniado; Babeth Rabinowitz; Uri Seligsohn

doi:10.1016/0002-9149(89)90463-3

Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction

Gabriel I. Barbash^*, Hanoch Hod, Shemuel Rath, Hilton I. Miller, Arie Roth, Yedahel Har-Zahav, Michaela Modan, Zeev Rotstein, Alex Batler, Ariela Zivelin, Joseph Charnilass, Elieser Kaplinsky, Shlomo Laniado, Babeth Rabinowitz, Uri Seligsohn

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Reocclusion of reperfused coronary arteries is a major setback that erodes the initial gain obtained by thrombolytic therapy in patients with acute myocardial infarction (AMI).₁ After thrombolysis with recombinant tissue-type plasminogen activator (rt-PA), early in-hospital reocclusion is observed in 20 to 45% of successfully treated patients.² Although maintenance infusion of rt-PA reduces the incidence of reocclusion during the in-hospital period,³ very early reocclusions immediately after⁴ or even during continuous rt-PA infusion can occur.^5,6 We describe 15 patients among 190 patients with AM1 treated with rt-PA in whom initial clinical signs of reperfusion were followed by clinical and electrocardiographic evidence of rt-PA dose-related reocclusion-reperfusion cycles.

Original language	English
Pages (from-to)	225-228
Number of pages	4
Journal	American Journal of Cardiology
Volume	64
Issue number	3
DOIs	https://doi.org/10.1016/0002-9149(89)90463-3
State	Published - 15 Jul 1989
Externally published	Yes

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Barbash, G. I., Hod, H., Rath, S., Miller, H. I., Roth, A., Har-Zahav, Y., Modan, M., Rotstein, Z., Batler, A., Zivelin, A., Charnilass, J., Kaplinsky, E., Laniado, S., Rabinowitz, B., & Seligsohn, U. (1989). Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction. American Journal of Cardiology, 64(3), 225-228. https://doi.org/10.1016/0002-9149(89)90463-3

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title = "Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction",

abstract = "Reocclusion of reperfused coronary arteries is a major setback that erodes the initial gain obtained by thrombolytic therapy in patients with acute myocardial infarction (AMI).1 After thrombolysis with recombinant tissue-type plasminogen activator (rt-PA), early in-hospital reocclusion is observed in 20 to 45% of successfully treated patients.2 Although maintenance infusion of rt-PA reduces the incidence of reocclusion during the in-hospital period,3 very early reocclusions immediately after4 or even during continuous rt-PA infusion can occur.5,6 We describe 15 patients among 190 patients with AM1 treated with rt-PA in whom initial clinical signs of reperfusion were followed by clinical and electrocardiographic evidence of rt-PA dose-related reocclusion-reperfusion cycles.",

author = "Barbash, {Gabriel I.} and Hanoch Hod and Shemuel Rath and Miller, {Hilton I.} and Arie Roth and Yedahel Har-Zahav and Michaela Modan and Zeev Rotstein and Alex Batler and Ariela Zivelin and Joseph Charnilass and Elieser Kaplinsky and Shlomo Laniado and Babeth Rabinowitz and Uri Seligsohn",

year = "1989",

month = jul,

day = "15",

doi = "10.1016/0002-9149(89)90463-3",

language = "אנגלית",

volume = "64",

pages = "225--228",

journal = "American Journal of Cardiology",

issn = "0002-9149",

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}

Barbash, GI , Hod, H , Rath, S , Miller, HI, Roth, A, Har-Zahav, Y, Modan, M, Rotstein, Z, Batler, A, Zivelin, A, Charnilass, J, Kaplinsky, E , Laniado, S , Rabinowitz, B & Seligsohn, U 1989, 'Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction', American Journal of Cardiology, vol. 64, no. 3, pp. 225-228. https://doi.org/10.1016/0002-9149(89)90463-3

TY - JOUR

T1 - Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction

AU - Barbash, Gabriel I.

AU - Hod, Hanoch

AU - Rath, Shemuel

AU - Miller, Hilton I.

AU - Roth, Arie

AU - Har-Zahav, Yedahel

AU - Modan, Michaela

AU - Rotstein, Zeev

AU - Batler, Alex

AU - Zivelin, Ariela

AU - Charnilass, Joseph

AU - Kaplinsky, Elieser

AU - Laniado, Shlomo

AU - Rabinowitz, Babeth

AU - Seligsohn, Uri

PY - 1989/7/15

Y1 - 1989/7/15

N2 - Reocclusion of reperfused coronary arteries is a major setback that erodes the initial gain obtained by thrombolytic therapy in patients with acute myocardial infarction (AMI).1 After thrombolysis with recombinant tissue-type plasminogen activator (rt-PA), early in-hospital reocclusion is observed in 20 to 45% of successfully treated patients.2 Although maintenance infusion of rt-PA reduces the incidence of reocclusion during the in-hospital period,3 very early reocclusions immediately after4 or even during continuous rt-PA infusion can occur.5,6 We describe 15 patients among 190 patients with AM1 treated with rt-PA in whom initial clinical signs of reperfusion were followed by clinical and electrocardiographic evidence of rt-PA dose-related reocclusion-reperfusion cycles.

AB - Reocclusion of reperfused coronary arteries is a major setback that erodes the initial gain obtained by thrombolytic therapy in patients with acute myocardial infarction (AMI).1 After thrombolysis with recombinant tissue-type plasminogen activator (rt-PA), early in-hospital reocclusion is observed in 20 to 45% of successfully treated patients.2 Although maintenance infusion of rt-PA reduces the incidence of reocclusion during the in-hospital period,3 very early reocclusions immediately after4 or even during continuous rt-PA infusion can occur.5,6 We describe 15 patients among 190 patients with AM1 treated with rt-PA in whom initial clinical signs of reperfusion were followed by clinical and electrocardiographic evidence of rt-PA dose-related reocclusion-reperfusion cycles.

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AN - SCOPUS:0024328183

SN - 0002-9149

VL - 64

SP - 225

EP - 228

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 3

ER -

Intermittent, dose-related fluctuations of pain and ST elevation during infusion of recombinant tissue plasminogen activator during acute myocardial infarction

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