Interleukin-2 production by human pre-implantation embryos

R. Orvieto, I. Bar-Hava, A. Schwartz, M. Shelef, Z. Ben-Rafael

Research output: Contribution to journalArticlepeer-review


The study was conducted to determine whether pre-implantation embryos secrete interleukin-2. Conditioned media of 27 embryos derived from women during in vitro fertilization (IVF) cycles were analyzed for interleukin-2 concentration. The results showed that conditioned embryo medium from the two pronuclei stage of 24 hours later contains interleukin-2. Endometrial large granular lymphocytes, which are probably involved in placentation, replicate in response to interleukin-2. It may therefore be speculated that interleukin-2 secreted by human embryos may modulate the function and replication of large granular lymphocytes.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalGynecological Endocrinology
Issue number5
StatePublished - 1997


  • In vitro fertilization
  • Interleukin-2
  • Pre-implantation embryos


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