Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome

Guy Gutman, L. Soussan-Gutman, M. Malcov, J. B. Lessing, A. Amit, F. Azem*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Problem: The presence of interleukin-18 (IL-18) in serum and pre-ovulatory follicular fluid (FF) and its possible correlation to in-vitro fertilization/embryo transfer (IVF/ET) outcome and ovarian hyperstimulation syndrome (OHSS) development. Method of study: A prospective study was carried out. Assays for serum and pooled pre-ovulatory FF levels of IL-18 were performed on 30 patients who underwent oocyte retrieval for IVF/ET. Results: Mean serum and FF levels of IL-18 were 370.4 ± 224 and 228.9 ± 208 pg/mL, respectively (r = 0.77, P < 0.0001). Levels of FF IL-18 were comparable between the two ovaries (right = 221 ± 166.8 pg/mL, left = 237 ± 171.9 pg/mL; r = 0.7550, P = 0.49). A positive correlation was found between IL-18 FF levels and number of retrieved oocytes (r = 0.45; P = 0.019). In three patients (10%) who developed OHSS, the mean serum level of IL-18 at day of ovum pickup was significantly higher compared with patients without OHSS (620 ± 196 pg/mL versus 345 ± 251 pg/mL, respectively, P = 0.04). Conclusions: Both pre-ovulatory FF and serum levels of IL-18 correlate with the number of retrieved oocytes. The serum IL-18 level at day of ovum pickup may predict consequent development of OHSS. Further investigations are warranted to determine the role of IL-18 in the folliculogenesis and OHSS pathogenesis.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Issue number5
StatePublished - May 2004
Externally publishedYes


  • Follicular fluid
  • IL-18
  • Oocyte retrieval
  • Ovarian hyperstimulation syndrome
  • Pregnancy rate


Dive into the research topics of 'Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome'. Together they form a unique fingerprint.

Cite this