Interleukin 10 receptor signaling: Master regulator of intestinal mucosal homeostasis in mice and humans

Dror S. Shouval, Jodie Ouahed, Amlan Biswas, Jeremy A. Goettel, Bruce H. Horwitz, Christoph Klein, Aleixo M. Muise, Scott B. Snapper

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. Here, we review recent findings on how IL10- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine gastrointestinal tract, with implications of their role in the prevention of inflammatory bowel disease (IBD). In addition, we discuss the impact of IL10 and IL10R signaling defects in humans and their relationship to very early-onset IBD (VEO-IBD).

Original languageEnglish
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Pages177-210
Number of pages34
DOIs
StatePublished - 2014
Externally publishedYes

Publication series

NameAdvances in Immunology
Volume122
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Keywords

  • Colitis
  • IBD
  • IL10
  • IL10 receptor
  • Microbiome
  • Very early-onset IBD

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