Interleukin-10 in preovulatory follicular fluid of patients undergoing in-vitro fertilization and embryo transfer

Eli Geva, Joseph B. Lessing, Liat Lerner-Geva, Foad Azem, Israel Yovel, Dalit Ben-Yosef, Uriel Barkai, Ami Amit

Research output: Contribution to journalArticlepeer-review

Abstract

Problem: The present study aimed at investigating the presence of Interleukin-10 (IL-10) in preovulatory follicular fluid (FF) and its possible correlation with 17-β-estradiol (E2) and progesterone (P) levels, and treatment outcome in patients undergoing in-vitro fertilization-embryo transfer (IVF-ET). Methods: Twenty consecutive patients with tubal factor infertility who underwent oocyte retrieval for IVF-ET were assayed for pooled, preovulatory FF levels of IL-10, E2, and P. Results: The mean FF levels of IL-10, E2, and P were 78.7 ± 104.7 pg/ml, 2787.0 ± 726.1 pg/ml, and 1.5 ± 0.8 ng/ml, respectively. No correlation was found between preovulatory FF concentration of IL-10, E2, oocyte number, oocyte fertilization rate, embryo quality, and pregnancy rate. The levels of IL-10 were found to be negatively correlated with P concentration, although not significantly (P = 0.057). Conclusion: Interleukin-10 exists in the preovulatory FF. Further investigations are needed to determine the role of IL-10 in the folliculogenesis.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume37
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Follicular fluid
  • Interleukin-10
  • Ovulation

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