TY - JOUR
T1 - Interleukin-10 in preovulatory follicular fluid of patients undergoing in-vitro fertilization and embryo transfer
AU - Geva, Eli
AU - Lessing, Joseph B.
AU - Lerner-Geva, Liat
AU - Azem, Foad
AU - Yovel, Israel
AU - Ben-Yosef, Dalit
AU - Barkai, Uriel
AU - Amit, Ami
PY - 1997
Y1 - 1997
N2 - Problem: The present study aimed at investigating the presence of Interleukin-10 (IL-10) in preovulatory follicular fluid (FF) and its possible correlation with 17-β-estradiol (E2) and progesterone (P) levels, and treatment outcome in patients undergoing in-vitro fertilization-embryo transfer (IVF-ET). Methods: Twenty consecutive patients with tubal factor infertility who underwent oocyte retrieval for IVF-ET were assayed for pooled, preovulatory FF levels of IL-10, E2, and P. Results: The mean FF levels of IL-10, E2, and P were 78.7 ± 104.7 pg/ml, 2787.0 ± 726.1 pg/ml, and 1.5 ± 0.8 ng/ml, respectively. No correlation was found between preovulatory FF concentration of IL-10, E2, oocyte number, oocyte fertilization rate, embryo quality, and pregnancy rate. The levels of IL-10 were found to be negatively correlated with P concentration, although not significantly (P = 0.057). Conclusion: Interleukin-10 exists in the preovulatory FF. Further investigations are needed to determine the role of IL-10 in the folliculogenesis.
AB - Problem: The present study aimed at investigating the presence of Interleukin-10 (IL-10) in preovulatory follicular fluid (FF) and its possible correlation with 17-β-estradiol (E2) and progesterone (P) levels, and treatment outcome in patients undergoing in-vitro fertilization-embryo transfer (IVF-ET). Methods: Twenty consecutive patients with tubal factor infertility who underwent oocyte retrieval for IVF-ET were assayed for pooled, preovulatory FF levels of IL-10, E2, and P. Results: The mean FF levels of IL-10, E2, and P were 78.7 ± 104.7 pg/ml, 2787.0 ± 726.1 pg/ml, and 1.5 ± 0.8 ng/ml, respectively. No correlation was found between preovulatory FF concentration of IL-10, E2, oocyte number, oocyte fertilization rate, embryo quality, and pregnancy rate. The levels of IL-10 were found to be negatively correlated with P concentration, although not significantly (P = 0.057). Conclusion: Interleukin-10 exists in the preovulatory FF. Further investigations are needed to determine the role of IL-10 in the folliculogenesis.
KW - Follicular fluid
KW - Interleukin-10
KW - Ovulation
UR - http://www.scopus.com/inward/record.url?scp=0031040880&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.1997.tb00211.x
DO - 10.1111/j.1600-0897.1997.tb00211.x
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0031040880
SN - 8755-8920
VL - 37
SP - 187
EP - 190
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 2
ER -