Interleaved 1H and 31P spectroscopic imaging for studying regional brain injury

L. H. Chang*, Y. Cohen, P. R. Weinstein, L. Chileuitt, T. L. James

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We present a new approach for in vivo localized spectroscopy which combines 1H and 31P one-dimensional spectroscopic imaging pulse sequences in an interleaved, time-shared manner using a surface coil. This approach was used to acquire metabolic information from a rat brain with regional ischemia at 4.7 Tesla. Spectra with very good signal-to-noise ratios, void of chemical shift artifacts, are obtainable from voxel sizes less than 0.3 cm3 in 40 min. Advantages and drawbacks of the proposed methodology are discussed.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalMagnetic Resonance Imaging
Issue number2
StatePublished - 1991
Externally publishedYes


FundersFunder number
National Institutes of Health
National Institute of Neurological Disorders and StrokeR01NS022022
United States-Israel Binational Science Foundation


    • Brain ischemia
    • Chemical shift imaging
    • H NMR
    • P NMR
    • Spatial localization


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