Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)

Patrick Hole, Katherine Sillence, Claire Hannell, Ciaran Manus Maguire, Matthias Roesslein, Guillaume Suarez, Sonja Capracotta, Zuzana Magdolenova, Limor Horev-Azaria, Agnieszka Dybowska, Laura Cooke, Andrea Haase, Servane Contal, Stein Manø, Antje Vennemann, Jeans Jacques Sauvain, Kieran Crosbie Staunton, Sergio Anguissola, Andreas Luch, Maria DusinskaRafi Korenstein, Arno C. Gutleb, Martin Wiemann, Adriele Prina-Mello, Michael Riediker, Peter Wick

Research output: Contribution to journalArticlepeer-review


One of the key challenges in the field of nanoparticle (NP) analysis is in producing reliable and reproducible characterisation data for nanomaterials. This study looks at the reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on a range of particle sizes and materials in several different media. It describes the protocol development and presents both the data and analysis of results obtained from 12 laboratories, mostly based in Europe, who are primarily QualityNano members. QualityNano is an EU FP7 funded Research Infrastructure that integrates 28 European analytical and experimental facilities in nanotechnology, medicine and natural sciences with the goal of developing and implementing best practice and quality in all aspects of nanosafety assessment. This study looks at both the development of the protocol and how this leads to highly reproducible results amongst participants. In this study, the parameter being measured is the modal particle size.

Original languageEnglish
JournalJournal of Nanoparticle Research
Issue number12
StatePublished - Dec 2013


  • Health and safety implications
  • Interlaboratory comparison
  • Nanoparticle
  • Polydispersity
  • Reproducibility
  • Toxicology


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