Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

T. O. Rosenbach, S. Moshonov, U. Zor, M. Yaron

Research output: Contribution to journalArticlepeer-review

Abstract

From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalClinical Rheumatology
Volume3
Issue number3
DOIs
StatePublished - Sep 1984

Keywords

  • Auto-Immune Disease
  • Interferon
  • Synovitis

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