Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

T. O. Rosenbach; S. Moshonov; U. Zor; M. Yaron

doi:10.1007/BF02032343

Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

T. O. Rosenbach, S. Moshonov, U. Zor, M. Yaron

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

Original language	English
Pages (from-to)	361-364
Number of pages	4
Journal	Clinical Rheumatology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1007/BF02032343
State	Published - Sep 1984

Keywords

Auto-Immune Disease
Interferon
Synovitis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02032343

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abstract = "From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.",

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AU - Moshonov, S.

AU - Zor, U.

AU - Yaron, M.

PY - 1984/9

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N2 - From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

AB - From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

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KW - Interferon

KW - Synovitis

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Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

Abstract

Keywords

UN SDGs

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