Interferon-related mental deterioration and behavioral changes in patients with renal cell carcinoma

Ofer Merimsky; Irith Reider-Groswasser; Moshe Inbar; Samario Chaitchik

doi:10.1016/0277-5379(90)90086-9

Interferon-related mental deterioration and behavioral changes in patients with renal cell carcinoma

Ofer Merimsky^*, Irith Reider-Groswasser, Moshe Inbar, Samario Chaitchik

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Five out of 38 patients (13%) with metastatic renal cell carcinoma had mental deterioration 3 weeks to 13 months after the start of treatment with recombinant interferon alpha-C. Metastatic spread to the brain, paraneoplastic effect of the tumor on the central nervous system and other causes of dementia were excluded. Computed tomography of the brain in these patients was normal and the width of the cerebral sulci and ventricles did not correlate with the severity of dementia. Specific patterns of atrophy were not seen. General deterioration, assessed by the change in Karnofsky performance status, was associated with dementia. The dementia may have been caused by a neurotoxic effect of interferon.

Original language	English
Pages (from-to)	596-600
Number of pages	5
Journal	European Journal of Cancer and Clinical Oncology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/0277-5379(90)90086-9
State	Published - 1990

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10.1016/0277-5379(90)90086-9

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abstract = "Five out of 38 patients (13%) with metastatic renal cell carcinoma had mental deterioration 3 weeks to 13 months after the start of treatment with recombinant interferon alpha-C. Metastatic spread to the brain, paraneoplastic effect of the tumor on the central nervous system and other causes of dementia were excluded. Computed tomography of the brain in these patients was normal and the width of the cerebral sulci and ventricles did not correlate with the severity of dementia. Specific patterns of atrophy were not seen. General deterioration, assessed by the change in Karnofsky performance status, was associated with dementia. The dementia may have been caused by a neurotoxic effect of interferon.",

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AU - Reider-Groswasser, Irith

AU - Inbar, Moshe

AU - Chaitchik, Samario

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AB - Five out of 38 patients (13%) with metastatic renal cell carcinoma had mental deterioration 3 weeks to 13 months after the start of treatment with recombinant interferon alpha-C. Metastatic spread to the brain, paraneoplastic effect of the tumor on the central nervous system and other causes of dementia were excluded. Computed tomography of the brain in these patients was normal and the width of the cerebral sulci and ventricles did not correlate with the severity of dementia. Specific patterns of atrophy were not seen. General deterioration, assessed by the change in Karnofsky performance status, was associated with dementia. The dementia may have been caused by a neurotoxic effect of interferon.

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Interferon-related mental deterioration and behavioral changes in patients with renal cell carcinoma

Abstract

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