Interferon-β-related DNA on human chromosome 4

Anurag D. Sagar; Pravinkumar B. Sehgal; Lester T. May; Doris L. Slate; Lester Shulman; Peter E. Barker; Frank H. Ruddle

doi:10.1007/BF01534418

Interferon-β-related DNA on human chromosome 4

Anurag D. Sagar, Pravinkumar B. Sehgal^*, Lester T. May, Doris L. Slate, Lester Shulman, Peter E. Barker, Frank H. Ruddle

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A DNA subclone (pPE-4000) derived from the λB4 interferon-β-related human genomic DNA clone was used as a probe in blot-hybridization experiments of DNA from a panel of human-rodent somatic cell hybrids containing overlapping subsets of human chromosomes. The DNA hybridization experiments showed that the λB4 IFN-β locus is localized to human chromosome 4. A provisional regional assignment to 4q12-qter was also obtained. Thus available hybridization data implicate human chromosomes 2, 4, and 9 in the human IFN-β system while the available biological data also implicated human chromosome 5.

Original language	English
Pages (from-to)	403-408
Number of pages	6
Journal	Somatic Cell and Molecular Genetics
Volume	11
Issue number	4
DOIs	https://doi.org/10.1007/BF01534418
State	Published - Jul 1985
Externally published	Yes

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title = "Interferon-β-related DNA on human chromosome 4",

abstract = "A DNA subclone (pPE-4000) derived from the λB4 interferon-β-related human genomic DNA clone was used as a probe in blot-hybridization experiments of DNA from a panel of human-rodent somatic cell hybrids containing overlapping subsets of human chromosomes. The DNA hybridization experiments showed that the λB4 IFN-β locus is localized to human chromosome 4. A provisional regional assignment to 4q12-qter was also obtained. Thus available hybridization data implicate human chromosomes 2, 4, and 9 in the human IFN-β system while the available biological data also implicated human chromosome 5.",

author = "Sagar, {Anurag D.} and Sehgal, {Pravinkumar B.} and May, {Lester T.} and Slate, {Doris L.} and Lester Shulman and Barker, {Peter E.} and Ruddle, {Frank H.}",

year = "1985",

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AU - Sagar, Anurag D.

AU - Sehgal, Pravinkumar B.

AU - May, Lester T.

AU - Slate, Doris L.

AU - Shulman, Lester

AU - Barker, Peter E.

AU - Ruddle, Frank H.

PY - 1985/7

Y1 - 1985/7

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AB - A DNA subclone (pPE-4000) derived from the λB4 interferon-β-related human genomic DNA clone was used as a probe in blot-hybridization experiments of DNA from a panel of human-rodent somatic cell hybrids containing overlapping subsets of human chromosomes. The DNA hybridization experiments showed that the λB4 IFN-β locus is localized to human chromosome 4. A provisional regional assignment to 4q12-qter was also obtained. Thus available hybridization data implicate human chromosomes 2, 4, and 9 in the human IFN-β system while the available biological data also implicated human chromosome 5.

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IS - 4

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Interferon-β-related DNA on human chromosome 4

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