Interferon-β-related DNA is dispersed in the human genome

Anurag D. Sagar, Pravinkumar B. Sehgal*, Lester T. May, Masayori Inouye, Doris L. Slate, Lester Shulman, Frank H. Ruddle

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Interferon-β1 (IFN-β1) complementary DNA was used as a hybridization probe to isolate human genomic DNA clones λB3 and λB4 from a human genomic DNA library. Blot-hybridization procedures and partial nucleotide sequencing revealed that λB3 is related to IFN-β1 (and more distantly to IFN-α1). Analyses of DNA obtained from a panel of human-rodent somatic cell hybrids that were probed with DNA derived from λB3 showed that λB3 is on human chromosome 2. Similar experiments indicated that λB4 is not on human chromosomes 2, 5, or 9. The finding that DNA related to the IFN- β1 gene (and IFN-α1 gene) is dispersed in the human genome raises new questions about the origins of the interferon genes.

Original languageEnglish
Pages (from-to)1312-1315
Number of pages4
Issue number4642
StatePublished - 1984
Externally publishedYes


FundersFunder number
National Institute of Allergy and Infectious DiseasesR01AI016262


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