Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae

Gili Regev-Yochay*, Krzysztof Trzciński, Claudette M. Thompson, Richard Malley, Marc Lipsitch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were eonpneumococcal sirepiococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.

Original languageEnglish
Pages (from-to)4996-5001
Number of pages6
JournalJournal of Bacteriology
Volume188
Issue number13
DOIs
StatePublished - Jul 2006
Externally publishedYes

Funding

FundersFunder number
National Institute of Allergy and Infectious DiseasesR01AI067737

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