Interface Fluid Syndrome 2 Decades After Laser-Assisted In situ Keratomileusis

Elishai Assayag*, David Smadja, Eduardo Roditi, David Zadok, Adi Abulafia, Yishay Weill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose:To report a case of late-onset interface fluid syndrome (IFS) after laser-assisted in situ keratomileusis (LASIK).Methods:A 94-year-old man was referred for evaluation because of persistent corneal edema 10 days after Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) for pseudophakic bullous keratopathy.Results:After an uneventful DSAEK, the patient was treated with topical antibiotics and steroids. On presentation, a well positioned and oriented DSAEK graft was observed in the right eye, yet the cornea was edematous. Applanation tonometry was normal. Anterior-segment optical coherence tomography (AS-OCT) revealed a LASIK flap with a fluid cleft beneath it. Requery confirmed that LASIK was performed 21 years ago. Topical steroids were stopped, and after 2 weeks, the cornea was clear, and AS-OCT revealed complete resolution of the interface fluid.Conclusions:Even decades later, IFS should be considered as a source of corneal edema in patients after LASIK. Monitoring these patients with AS-OCT is recommended.

Original languageEnglish
Pages (from-to)381-382
Number of pages2
JournalEye and Contact Lens
Issue number6
StatePublished - 1 Jun 2021
Externally publishedYes


  • Corneal edema
  • Interface fluid syndrome
  • Pressure-induced stromal keratitis


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