TY - JOUR
T1 - Intercellular exchange of proteins
T2 - The immune cell habit of sharing
AU - Rechavi, Oded
AU - Goldstein, Itamar
AU - Kloog, Yoel
N1 - Funding Information:
We thank S.R. Smith for editorial assistance. This work was supported by the Israel Science Foundation (Grant no. 912/06). Yoel Kloog is the incumbent of The Jack H. Skirball Chair for Applied Neurobiology. Oded Rechavi is supported by a scholarship from the Clore Israel Foundation.
PY - 2009/6/5
Y1 - 2009/6/5
N2 - The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional "proteome mixing" among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these "unsplittable" units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins-trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.
AB - The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional "proteome mixing" among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these "unsplittable" units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins-trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.
KW - Intercellular protein transfer
KW - Proteomics
KW - Ras
KW - Trogocytosis
UR - http://www.scopus.com/inward/record.url?scp=67349280860&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2009.03.014
DO - 10.1016/j.febslet.2009.03.014
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AN - SCOPUS:67349280860
SN - 0014-5793
VL - 583
SP - 1792
EP - 1799
JO - FEBS Letters
JF - FEBS Letters
IS - 11
ER -