Intercellular exchange of proteins: The immune cell habit of sharing

Oded Rechavi; Itamar Goldstein; Yoel Kloog

doi:10.1016/j.febslet.2009.03.014

Intercellular exchange of proteins: The immune cell habit of sharing

Oded Rechavi, Itamar Goldstein, Yoel Kloog^*

^*Corresponding author for this work

Department of Neurobiology

Research output: Contribution to journal › Short survey › peer-review

Abstract

The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional "proteome mixing" among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these "unsplittable" units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins-trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.

Original language	English
Pages (from-to)	1792-1799
Number of pages	8
Journal	FEBS Letters
Volume	583
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2009.03.014
State	Published - 5 Jun 2009

Keywords

Intercellular protein transfer
Proteomics
Ras
Trogocytosis

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10.1016/j.febslet.2009.03.014

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title = "Intercellular exchange of proteins: The immune cell habit of sharing",

abstract = "The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional {"}proteome mixing{"} among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these {"}unsplittable{"} units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins-trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.",

keywords = "Intercellular protein transfer, Proteomics, Ras, Trogocytosis",

author = "Oded Rechavi and Itamar Goldstein and Yoel Kloog",

note = "Funding Information: We thank S.R. Smith for editorial assistance. This work was supported by the Israel Science Foundation (Grant no. 912/06). Yoel Kloog is the incumbent of The Jack H. Skirball Chair for Applied Neurobiology. Oded Rechavi is supported by a scholarship from the Clore Israel Foundation.",

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doi = "10.1016/j.febslet.2009.03.014",

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T1 - Intercellular exchange of proteins

T2 - The immune cell habit of sharing

AU - Rechavi, Oded

AU - Goldstein, Itamar

AU - Kloog, Yoel

N1 - Funding Information: We thank S.R. Smith for editorial assistance. This work was supported by the Israel Science Foundation (Grant no. 912/06). Yoel Kloog is the incumbent of The Jack H. Skirball Chair for Applied Neurobiology. Oded Rechavi is supported by a scholarship from the Clore Israel Foundation.

PY - 2009/6/5

Y1 - 2009/6/5

N2 - The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional "proteome mixing" among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these "unsplittable" units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins-trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.

AB - The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional "proteome mixing" among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these "unsplittable" units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins-trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.

KW - Intercellular protein transfer

KW - Proteomics

KW - Ras

KW - Trogocytosis

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DO - 10.1016/j.febslet.2009.03.014

M3 - סקירה קצרה

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VL - 583

SP - 1792

EP - 1799

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 11

ER -

Intercellular exchange of proteins: The immune cell habit of sharing

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Keywords

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