TY - JOUR
T1 - Interactions of the GnRH receptor with heterotrimeric G proteins
AU - Naor, Zvi
AU - Huhtaniemi, Ilpo
N1 - Funding Information:
We thank Drs. Adam Pawson and Craig MaCardle for their help and Boris Shterntal for drawing the models. This work was supported by U.S.-Israel Binational Science Foundation Grant 2007057, The Israel Science Foundation, Grant 2011-2015, and the Adams Super-Center for Brain Studies at Tel-Aviv University. Z.N. is the incumbent of the Abraham E. Kazan Chair in Structural Biology.
PY - 2013/4
Y1 - 2013/4
N2 - G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner.
AB - G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner.
KW - G proteins
KW - GnRH receptor
KW - Pituitary gonadotropes
KW - Sex hormone-dependent cancer cells
UR - http://www.scopus.com/inward/record.url?scp=84877642932&partnerID=8YFLogxK
U2 - 10.1016/j.yfrne.2012.11.001
DO - 10.1016/j.yfrne.2012.11.001
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AN - SCOPUS:84877642932
SN - 0091-3022
VL - 34
SP - 88
EP - 94
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
IS - 2
ER -
