Interactions of the GnRH receptor with heterotrimeric G proteins

Zvi Naor, Ilpo Huhtaniemi

Research output: Contribution to journalReview articlepeer-review

Abstract

G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalFrontiers in Neuroendocrinology
Volume34
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • G proteins
  • GnRH receptor
  • Pituitary gonadotropes
  • Sex hormone-dependent cancer cells

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