Interactions between chlorpromazine and some of its metabolites

Sara Shavit, I. Kutz, A. D. Korczyn*, S. Gitter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The interaction between chlorpromazine (CPZ) and four of its major metabolites 7-hydroxy-CPZ, 8-hydroxy-CPZ, desmethyl-CPZ and CPZ sulfoxide was determined in experimental models of antipsychotic activity. None of the metabolites antagonized any of the CPZ effects. All of them had an additive effect to CPZ in reducing spontaneous motor activity. Prolongation of barbiturate sleeping time induced by CPZ and the abolition of amphetamine induced stereotyped behaviour by CPZ were found to be potentiated by 7-hydroxy-CPZ, but not by the other metabolites.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalCommunications In Psychopharmacology
Issue number6
StatePublished - 1980


Dive into the research topics of 'Interactions between chlorpromazine and some of its metabolites'. Together they form a unique fingerprint.

Cite this