Abstract
The interaction between chlorpromazine (CPZ) and four of its major metabolites 7-hydroxy-CPZ, 8-hydroxy-CPZ, desmethyl-CPZ and CPZ sulfoxide was determined in experimental models of antipsychotic activity. None of the metabolites antagonized any of the CPZ effects. All of them had an additive effect to CPZ in reducing spontaneous motor activity. Prolongation of barbiturate sleeping time induced by CPZ and the abolition of amphetamine induced stereotyped behaviour by CPZ were found to be potentiated by 7-hydroxy-CPZ, but not by the other metabolites.
| Original language | English |
|---|---|
| Pages (from-to) | 495-500 |
| Number of pages | 6 |
| Journal | Communications In Psychopharmacology |
| Volume | 4 |
| Issue number | 6 |
| State | Published - 1980 |