Interaction of ubiquinone and vitamin K3 with mitochondrial succinate-ubiquinone oxidoreductase

Alexander B. Kotlyar*, Menahem Gutman, Brian A.C. Ackrell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Two new methods have been devised for measuring fumarate reduction by beef heart succinate-ubiquinone oxidoreductase with quinols as electron donors. In one assay the quinone is maintained in the reduced state by coupling fumarate reduction with the DT diaphorase reaction, in the other assay by the presence of excess dithionite. The advantages of these methods are discussed, along with preliminary characterization of the quinol-protein interaction.

Original languageEnglish
Pages (from-to)1656-1662
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume186
Issue number3
DOIs
StatePublished - 14 Aug 1992

Funding

FundersFunder number
National Institutes of Health
National Heart, Lung, and Blood InstituteP01HL016251
Koret Foundation
U.S. Navy00014-89-J 1622
Ministry of Science and Technology, Israel

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