Interaction of phentolamine and noradrenaline on myocardial contractility and adenyl cyclase activity

Babeth Rabinowitz*, William W. Parmley, George Bonnoris, Leonard Chuck, Miriam Kligerman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

AUTHORS' SYNOPSIS: The effects of phentolamine and noradrenaline on force development of isolated papillary muscles and on the adenyl cyclase activity of the ventricular myocardium were studied in cats. Phentolamine alone did not influence either force or adenyl cyclase activity. Phentolamine attenuated the increase of both force and adenyl cyclase activity induced by noradrenaline, but did not alter the effects produced by isoprenaline. The present study demonstrates that phentolamine lacks direct positive inotropic effects, but attenuates the effects of noradrenaline.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalCardiovascular Research
Volume8
Issue number2
DOIs
StatePublished - Mar 1974
Externally publishedYes

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