Interaction of phentolamine and noradrenaline on myocardial contractility and adenyl cyclase activity

Babeth Rabinowitz; William W. Parmley; George Bonnoris; Leonard Chuck; Miriam Kligerman

doi:10.1093/cvr/8.2.243

Interaction of phentolamine and noradrenaline on myocardial contractility and adenyl cyclase activity

Babeth Rabinowitz^*, William W. Parmley, George Bonnoris, Leonard Chuck, Miriam Kligerman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

AUTHORS' SYNOPSIS: The effects of phentolamine and noradrenaline on force development of isolated papillary muscles and on the adenyl cyclase activity of the ventricular myocardium were studied in cats. Phentolamine alone did not influence either force or adenyl cyclase activity. Phentolamine attenuated the increase of both force and adenyl cyclase activity induced by noradrenaline, but did not alter the effects produced by isoprenaline. The present study demonstrates that phentolamine lacks direct positive inotropic effects, but attenuates the effects of noradrenaline.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	Cardiovascular Research
Volume	8
Issue number	2
DOIs	https://doi.org/10.1093/cvr/8.2.243
State	Published - Mar 1974
Externally published	Yes

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abstract = "AUTHORS' SYNOPSIS: The effects of phentolamine and noradrenaline on force development of isolated papillary muscles and on the adenyl cyclase activity of the ventricular myocardium were studied in cats. Phentolamine alone did not influence either force or adenyl cyclase activity. Phentolamine attenuated the increase of both force and adenyl cyclase activity induced by noradrenaline, but did not alter the effects produced by isoprenaline. The present study demonstrates that phentolamine lacks direct positive inotropic effects, but attenuates the effects of noradrenaline.",

author = "Babeth Rabinowitz and Parmley, {William W.} and George Bonnoris and Leonard Chuck and Miriam Kligerman",

year = "1974",

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doi = "10.1093/cvr/8.2.243",

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AU - Bonnoris, George

AU - Chuck, Leonard

AU - Kligerman, Miriam

PY - 1974/3

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AB - AUTHORS' SYNOPSIS: The effects of phentolamine and noradrenaline on force development of isolated papillary muscles and on the adenyl cyclase activity of the ventricular myocardium were studied in cats. Phentolamine alone did not influence either force or adenyl cyclase activity. Phentolamine attenuated the increase of both force and adenyl cyclase activity induced by noradrenaline, but did not alter the effects produced by isoprenaline. The present study demonstrates that phentolamine lacks direct positive inotropic effects, but attenuates the effects of noradrenaline.

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Interaction of phentolamine and noradrenaline on myocardial contractility and adenyl cyclase activity

Abstract

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