Interaction of phencyclidine and its new adamantyl derivatives with muscarinic receptors

Ayala Gabrielevitz*, Yoel Kloog, Asher Kalir, David Balderman, Mordechai Sokolovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The antimuscarinic potency of new derivatives of phencyclidine containing the adamantyl moiety was evaluated in the guinea pig ileum test. The drugs tested competitively inhibited the acetylcholine-induced contractions. Kd values were calculated and compared to those obtained by direct binding to the muscarinic receptors from mouse brain. The new derivative, |1-(2-phenyl-2-adamantyl) piperidine| was found to be the most potent muscarinic antagonist among the many phencyclidine derivatives known to date. The results are discussed in terms of the acetylcholine-like molecular arrangement of these derivatives that gives rise to a characteristic muscarinic interaction.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalLife Sciences
Volume26
Issue number2
DOIs
StatePublished - 14 Jan 1980

Fingerprint

Dive into the research topics of 'Interaction of phencyclidine and its new adamantyl derivatives with muscarinic receptors'. Together they form a unique fingerprint.

Cite this