Interaction of myelin basic protein with gangliosides and ganglioside-phospholipid mixtures

D. Bach*, B. Sela

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The interaction of myelin basic protein with monosialoganglioside GM1 was investigated. It was found that the emission maximum of the tryptophan of the protein is blue-shifted due to the interaction. In mixtures of the monosialoganglioside with phosphatidylcholine, the myelin basic protein induces phase separation of the lipids as inferred from differential scanning calorimetry experiments.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalBBA - Biomembranes
Volume819
Issue number2
DOIs
StatePublished - 10 Oct 1985

Funding

FundersFunder number
Multiple Sclerosis Society

    Keywords

    • Differential scanning calorimetry
    • Fluorescence
    • Ganglioside
    • Myelin basic protein

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