TY - JOUR
T1 - Interaction of group a streptococcal lipoteichoic acid with bovine myelin basic protein
AU - Ofek, Itzhak
AU - Whitaker, John N.
AU - Campbell, G. L.
AU - Beachey, Edwin H.
N1 - Funding Information:
This study was supported by program-directed research funds from the U.S. Veterans Administration and by grants no. AI-I0085 and AI-13350 from the U.S. Public Health Service. Dr. Beachey is the recipient of a Medical Investigatorship grant from the U.S.Veterans Administration.
PY - 1979/1
Y1 - 1979/1
N2 - Group A streptococcal lipoteichoic acid (LTA), a polyglycerol phosphate ester linked with fatty acids, formed precipitin lines in agar gels with the positively charged myelin basic protein (MBP) isolated from bovine brain. The LTA-MBP complexes were formed with deacylated teichoic acid and were not inhibited by monomeric glycerol phosphate, a finding indicating the participation of the polyglycerol phosphate (PGP) backbone of LTA in the reaction. Following interaction with PGP, MBP inhibited the agglutination of LTA-sensitized erythrocytes by induction of antibodies to LTA, directed against the PGP antigenic determinant. The amplification of the humoral immune response to the insoluble complex of LTA and MBP was of particular interest in view of the lack of immunogenicity of either LTA or MBP alone.
AB - Group A streptococcal lipoteichoic acid (LTA), a polyglycerol phosphate ester linked with fatty acids, formed precipitin lines in agar gels with the positively charged myelin basic protein (MBP) isolated from bovine brain. The LTA-MBP complexes were formed with deacylated teichoic acid and were not inhibited by monomeric glycerol phosphate, a finding indicating the participation of the polyglycerol phosphate (PGP) backbone of LTA in the reaction. Following interaction with PGP, MBP inhibited the agglutination of LTA-sensitized erythrocytes by induction of antibodies to LTA, directed against the PGP antigenic determinant. The amplification of the humoral immune response to the insoluble complex of LTA and MBP was of particular interest in view of the lack of immunogenicity of either LTA or MBP alone.
UR - http://www.scopus.com/inward/record.url?scp=0018348018&partnerID=8YFLogxK
U2 - 10.1093/infdis/139.1.93
DO - 10.1093/infdis/139.1.93
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AN - SCOPUS:0018348018
SN - 0022-1899
VL - 139
SP - 93
EP - 96
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -