Integrins in morphogenesis and signaling

B. Z. Katz*, K. M. Yamada

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Integrins are a family of heterodimeric transmembrane receptors that provide a physical and biochemical bridge between components of the extracellular matrix and the intracellular physiological environment. Binding of integrins to their ligands results in the formation of cytoplasmic multi-protein assemblies composed of both cytoskeletal and signaling molecules. The composition and activity of these assemblies is regulated by the nature of integrin-ligand interactions, as well as by intracellular regulators that include tyrosine kinases and phosphatases, PKC, and small GTPases. Integrin-mediated cellular physiological responses include the activation of signal transduction, cytoskeletal rearrangements, and co-regulation of growth factor activities. These responses, combined with integrin-mediated cell adhesion, play a major role in tissue morphogenesis and developmental processes.

Original languageEnglish
Pages (from-to)467-476
Number of pages10
Issue number8
StatePublished - Sep 1997
Externally publishedYes


  • Cytoskeleton
  • Focal adhesion
  • Integrin
  • Morphogenesis
  • Rho
  • Signal transduction
  • Tyrosine phosphorylation


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