Integration of PET/CT into the preoperative evaluation of patients with early cervical cancer does not decrease the proportion of patients with positive lymph nodes found after surgery

Ofer Gemer, Ram Eitan, Michael Gdalevich, Ala Mamanov, Benjamin Piura, Alex Rabinovich, Hanoch Levavi, Bozhena Saar-Ryss, Reuvit Halperin, Shahar Finci, Uzi Beller, Ilan Bruchim, Tally Levy, Inbar Ben-Shachar, Amichai Meirovitz, Alon Ben Arie, Ofer Lavie

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of this study was to evaluate whether preoperative positron emission tomography/computed tomography (PET/CT) in patients with early-stage cervical carcinoma reduced the proportion of patients with metastatic lymph nodes identified after surgery. Patients and Methods: This is a multicenter case-control study of 599 patients with early cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy at 1 of 10 gynecological oncology units in Israel. The patients were divided into 2 groups according to whether or not they underwent a preoperative PET/CT. The primary outcome was the proportion of patients with nodal involvement. The 2 groups were compared with regard to the clinical and histological variables. Results: Of the 599 patients who underwent surgery, 180 (36%) had preoperative PET/CT study. There were no significant differences between the PET/CT and control groups with regard to clinical and histological risk factors. The proportion of patients with involved nodes was similar in the control and PET/CT groups (20.8% vs 19%; P = 0.73) as well as the proportion of patients receiving adjuvant radiotherapy/chemoradiation (58.3% vs 55.1%; P = 0.55). Conclusions: Preoperative PET/CT in patients with early cervical cancer does not reduce proportion of patients with metastatic nodal involvement and the employment of multimodality treatment. Prospective clinical trials comparing management based on PET/CT findings are warranted.

Original languageEnglish
Pages (from-to)1461-1465
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume24
Issue number8
DOIs
StatePublished - 1 Oct 2014

Keywords

  • Cervical cancer
  • Lymph nodes
  • PET/CT
  • Surgery

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