Integrating innate and adaptive immune cells: Mast cells as crossroads between regulatory and effector B and T cells

Yoseph A. Mekori, Alon Y. Hershko, Barbara Frossi, Francesca Mion, Carlo E. Pucillo

Research output: Contribution to journalArticlepeer-review

Abstract

A diversity of immune mechanisms have evolved to protect normal tissues from infection, but from immune damage too. Innate cells, as well as adaptive cells, are critical contributors to the correct development of the immune response and of tissue homeostasis. There is a dynamic "cross-talk" between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage as well as the development of the immune response. Mast cells have shown a great plasticity, modifying their behavior at different stages of immune response through interaction with effector and regulatory populations of adaptive immunity. Understanding the interplays among T effectors, regulatory T cells, B cells and regulatory B cells with mast cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immune-modulator and -suppressor elements in the innate and adaptive immune system.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalEuropean Journal of Pharmacology
Volume778
DOIs
StatePublished - 5 May 2016

Keywords

  • B cells
  • B regcells
  • Mast cell
  • T effectorcells
  • T regcells

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