Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

Derek LeRoith; Martin Adamo; Haim Werner; Charles T. Roberts

doi:10.1016/1043-2760(91)90003-6

Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

Derek LeRoith^*
, Martin Adamo
, Haim Werner
, Charles T. Roberts

^*Corresponding author for this work

National Institutes of Health

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Abstract

Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.

Original language	English
Pages (from-to)	134-139
Number of pages	6
Journal	Trends in Endocrinology and Metabolism
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/1043-2760(91)90003-6
State	Published - 1991
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/1043-2760(91)90003-6

Cite this

@article{9586b13b44cf453e9fd2a90a483ec2b7,

title = "Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states",

abstract = "Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.",

author = "Derek LeRoith and Martin Adamo and Haim Werner and Roberts, \{Charles T.\}",

year = "1991",

doi = "10.1016/1043-2760(91)90003-6",

language = "אנגלית",

volume = "2",

pages = "134--139",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

AU - LeRoith, Derek

AU - Adamo, Martin

AU - Werner, Haim

AU - Roberts, Charles T.

PY - 1991

Y1 - 1991

N2 - Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.

AB - Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.

UR - https://www.scopus.com/pages/publications/0025767211

U2 - 10.1016/1043-2760(91)90003-6

DO - 10.1016/1043-2760(91)90003-6

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

AN - SCOPUS:0025767211

SN - 1043-2760

VL - 2

SP - 134

EP - 139

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 4

ER -

Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this