Abstract
Objectives: To assess insulin-related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood. Study design: Thirty-four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow-up was 3.6yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A1c (HbA1c ) and lipid profile were measured and compared. Results: HbA 1c was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group. Conclusions: Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.
Original language | English |
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Pages (from-to) | 149-154 |
Number of pages | 6 |
Journal | Pediatric Diabetes |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Bone marrow transplantation
- DM
- Glucose intolerance
- Thalassemia