Insulin-related metabolism following hematopoietic stem cell transplantation in childhood

Ronit Elhasid*, Yael A. Leshem, Myriam Weyl Ben Arush, Jacob M. Rowe, Naim Shehadeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objectives: To assess insulin-related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood. Study design: Thirty-four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow-up was 3.6yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A1c (HbA1c ) and lipid profile were measured and compared. Results: HbA 1c was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group. Conclusions: Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalPediatric Diabetes
Volume10
Issue number2
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • DM
  • Glucose intolerance
  • Thalassemia

Fingerprint

Dive into the research topics of 'Insulin-related metabolism following hematopoietic stem cell transplantation in childhood'. Together they form a unique fingerprint.

Cite this