Insulin-like growth factor-I and follicle-stimulating hormone suppress insulin-like growth factor binding protein-1 secretion by human granulosa-luteal cells

Jehoshua Dor*, Nadine Costritsci, Clara Pariente, Jaron Rabinovici, Shlomo Mashiach, Bruno Lunenfeld, Hanna Kaneti, Markku Seppälä, Riitta Koistinen, Avraham Karasik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Local regulation of insulin-like growth factor binding protein-1 (IGFBP-1) production in the human ovarian follicle was investigated using cultured human granulosa-luteal cells. Both insulin-like growth factor-I (IGF-I) and follicle-stimulating hormone (FSH) exerted a dual effect on granulosa cells: while cstradiol (E2) production was increased by both stimulants, the addition of either of the two hormones led to a reduction in IGFBP-1 secretion by more than 50%, Inhibition of IGFBP-1 production in response to IGF-I was dose-dependent, with the highest effect observed at 5 nM IGF-I. A significant correlation was found between the increase in E2 and inhibition of IGFBP-1 secretion in response to IGF-I. These observations may suggest a novel mechanism, at the follicular level, by which FSH and IGP-I amplify the IGF-I effect in the ovarian follicular cells.

Original languageEnglish
Pages (from-to)969-971
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume75
Issue number3
StatePublished - Sep 1992

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