Insulin detemir versus glyburide in women with gestational diabetes mellitus

Ronit Koren*, Eran Ashwal, Moshe Hod, Yoel Toledano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Aim: To evaluate the safety, efficacy and pregnancy outcomes of insulin detemir (IDet) versus glyburide treatment in women with gestational diabetes mellitus (GDM). Methods: We conducted a retrospective cohort study of women with GDM who were treated with either glyburide or IDet for GDM in a university-affiliated tertiary hospital. Results: Ninety-one patients with GDM were enrolled, 62 were administered glyburide and 29 IDet. Maternal age, pregestational body mass index (BMI) and rate of abnormal oral glucose tolerance test (OGTT) blood glucose values were not significantly different between groups. Good glycemic control rates were comparable. Hypoglycemic episodes were reported only in the glyburide group (19.4% versus 0%, p = 0.01). Maternal weight gain during pregnancy was significantly higher among women in the glyburide group (8.8 ± 5.1 kg, p < 0.001) compared to those in the IDet group (2.1 ± 19.9 kg, p = 0.71). Conclusions: To the best of our knowledge, this is the first study on IDet treatment in patients with GDM. By our preliminary results, IDet is a viable treatment option in women with GDM. Further large prospective studies are needed to determine the efficacy and safety of IDet in GDM patients.

Original languageEnglish
Pages (from-to)916-919
Number of pages4
JournalGynecological Endocrinology
Issue number11
StatePublished - 1 Nov 2016


  • Gestational diabetes
  • glyburide
  • hypoglycemia
  • insulin detemir


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