Insular cortex neurons encode and retrieve specific immune responses

Tamar Koren; Re'ee Yifa; Mariam Amer; Maria Krot; Nadia Boshnak; Tamar L. Ben-Shaanan; Hilla Azulay-Debby; Itay Zalayat; Eden Avishai; Haitham Hajjo; Maya Schiller; Hedva Haykin; Ben Korin; Dorit Farfara; Fahed Hakim; Oren Kobiler; Kobi Rosenblum; Asya Rolls

doi:10.1016/j.cell.2021.10.013

Insular cortex neurons encode and retrieve specific immune responses

Tamar Koren, Re'ee Yifa, Mariam Amer, Maria Krot, Nadia Boshnak, Tamar L. Ben-Shaanan, Hilla Azulay-Debby, Itay Zalayat, Eden Avishai, Haitham Hajjo, Maya Schiller, Hedva Haykin, Ben Korin, Dorit Farfara, Fahed Hakim, Oren Kobiler, Kobi Rosenblum, Asya Rolls^*

^*Corresponding author for this work

Clinical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Increasing evidence indicates that the brain regulates peripheral immunity, yet whether and how the brain represents the state of the immune system remains unclear. Here, we show that the brain's insular cortex (InsCtx) stores immune-related information. Using activity-dependent cell labeling in mice (Fos^TRAP), we captured neuronal ensembles in the InsCtx that were active under two different inflammatory conditions (dextran sulfate sodium [DSS]-induced colitis and zymosan-induced peritonitis). Chemogenetic reactivation of these neuronal ensembles was sufficient to broadly retrieve the inflammatory state under which these neurons were captured. Thus, we show that the brain can store and retrieve specific immune responses, extending the classical concept of immunological memory to neuronal representations of inflammatory information.

Original language	English
Pages (from-to)	5902-5915.e17
Journal	Cell
Volume	184
Issue number	24
DOIs	https://doi.org/10.1016/j.cell.2021.10.013
State	Published - 24 Nov 2021

Funding

Funders	Funder number
NIEMO
Wellcome Trust
Prince Center for Neurodegenerative Disorders
European Research Council
Howard Hughes Medical Institute
Horizon 2020 Framework Programme	758952

Keywords

engram
inflammation
insular cortex
memory
neurons
psychosomatic

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10.1016/j.cell.2021.10.013

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Koren, T., Yifa, R., Amer, M., Krot, M., Boshnak, N., Ben-Shaanan, T. L., Azulay-Debby, H., Zalayat, I., Avishai, E., Hajjo, H., Schiller, M., Haykin, H., Korin, B., Farfara, D., Hakim, F., Kobiler, O., Rosenblum, K., & Rolls, A. (2021). Insular cortex neurons encode and retrieve specific immune responses. Cell, 184(24), 5902-5915.e17. https://doi.org/10.1016/j.cell.2021.10.013

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title = "Insular cortex neurons encode and retrieve specific immune responses",

abstract = "Increasing evidence indicates that the brain regulates peripheral immunity, yet whether and how the brain represents the state of the immune system remains unclear. Here, we show that the brain's insular cortex (InsCtx) stores immune-related information. Using activity-dependent cell labeling in mice (FosTRAP), we captured neuronal ensembles in the InsCtx that were active under two different inflammatory conditions (dextran sulfate sodium [DSS]-induced colitis and zymosan-induced peritonitis). Chemogenetic reactivation of these neuronal ensembles was sufficient to broadly retrieve the inflammatory state under which these neurons were captured. Thus, we show that the brain can store and retrieve specific immune responses, extending the classical concept of immunological memory to neuronal representations of inflammatory information.",

keywords = "engram, inflammation, insular cortex, memory, neurons, psychosomatic",

author = "Tamar Koren and Re'ee Yifa and Mariam Amer and Maria Krot and Nadia Boshnak and Ben-Shaanan, {Tamar L.} and Hilla Azulay-Debby and Itay Zalayat and Eden Avishai and Haitham Hajjo and Maya Schiller and Hedva Haykin and Ben Korin and Dorit Farfara and Fahed Hakim and Oren Kobiler and Kobi Rosenblum and Asya Rolls",

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year = "2021",

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day = "24",

doi = "10.1016/j.cell.2021.10.013",

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Koren, T, Yifa, R, Amer, M, Krot, M, Boshnak, N, Ben-Shaanan, TL, Azulay-Debby, H, Zalayat, I, Avishai, E, Hajjo, H, Schiller, M, Haykin, H, Korin, B, Farfara, D, Hakim, F, Kobiler, O, Rosenblum, K & Rolls, A 2021, 'Insular cortex neurons encode and retrieve specific immune responses', Cell, vol. 184, no. 24, pp. 5902-5915.e17. https://doi.org/10.1016/j.cell.2021.10.013

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AU - Koren, Tamar

AU - Yifa, Re'ee

AU - Amer, Mariam

AU - Krot, Maria

AU - Boshnak, Nadia

AU - Ben-Shaanan, Tamar L.

AU - Azulay-Debby, Hilla

AU - Zalayat, Itay

AU - Avishai, Eden

AU - Hajjo, Haitham

AU - Schiller, Maya

AU - Haykin, Hedva

AU - Korin, Ben

AU - Farfara, Dorit

AU - Hakim, Fahed

AU - Kobiler, Oren

AU - Rosenblum, Kobi

AU - Rolls, Asya

PY - 2021/11/24

Y1 - 2021/11/24

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AB - Increasing evidence indicates that the brain regulates peripheral immunity, yet whether and how the brain represents the state of the immune system remains unclear. Here, we show that the brain's insular cortex (InsCtx) stores immune-related information. Using activity-dependent cell labeling in mice (FosTRAP), we captured neuronal ensembles in the InsCtx that were active under two different inflammatory conditions (dextran sulfate sodium [DSS]-induced colitis and zymosan-induced peritonitis). Chemogenetic reactivation of these neuronal ensembles was sufficient to broadly retrieve the inflammatory state under which these neurons were captured. Thus, we show that the brain can store and retrieve specific immune responses, extending the classical concept of immunological memory to neuronal representations of inflammatory information.

KW - engram

KW - inflammation

KW - insular cortex

KW - memory

KW - neurons

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JO - Cell

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ER -

Insular cortex neurons encode and retrieve specific immune responses

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