Insights on the functional role of chromatin remodelers in osteogenic cells

Dafna Benayahu, Nitsan Shacham, Irena Shur

Research output: Contribution to journalReview articlepeer-review

Abstract

Control of eukaryotic gene expression requires interaction between sequence-specific transcription factors and their regulatory elements on the particular promoter. The dynamic alteration of chromatin structure regulates the accessibility of these elements in the genome and therefore contributes to the control of transcrip-tional activity. Here we discuss chromatin remodelling in the context of osteoblast lineage regulation. This review specifically highlights the role of the protein chromatin-related mesenchymal modulator (CReMM/CHD9), a recently identified chromatin remodeler, in osteogenic cell differentiation.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalCritical Reviews in Eukaryotic Gene Expression
Volume17
Issue number2
DOIs
StatePublished - 2007

Keywords

  • CHD proteins
  • Chromatin remodeling
  • Mesenchymal cell differentiation

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