@article{91ee9e3967ea4a289135b4b94fe26525,
title = "Insight: Prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist: A proposed mechanism and management plan",
abstract = "We have previously described our data collected after administration of gonadotropin releasing hormone-agonist (GnRH-a) to delay sexual maturation, in premenarchal girls suffering from idiopathic central precocious puberty. 1 We have explained the recurrent episodes of bleeding due to discontinuation of the estrogen support of the proliferative and stable endometrium. The recognition in recent years of the extra-pituitary functions of GnRH-a, the ability of GnRH to stimulate prostaglandin production and the known role of prostaglandins in irregular vaginal bleeding prompted us to seek alternative explanations to our data.We suggest considering a potential clinical use of combination therapies of GnRH agonists and prostanoid receptor antagonists to treat central precocious puberty.",
keywords = "GnRH agonist, Precocious puberty, Prostaglandins, Vaginal bleeding",
author = "Arieh Kauschansky and Raoul Orvieto and Arie Yeshaya and Boris Shterntal and Zvi Naor",
note = "Funding Information: We thank Fiorenza Prezedecki for the help during this study. This research was supported by the Israel Science Foundation (Grant No. 221/05 ), the German-Israeli Foundation for Research and Development (Grant No. I-751-168.2/2002 ), U.S.-Israel Binational Science Foundation (Grant No. 2007057 ) and the Adams Super-Center for Brain Studies at Tel-Aviv University.",
year = "2011",
month = dec,
doi = "10.1016/j.jpag.2011.06.007",
language = "אנגלית",
volume = "24",
pages = "365--367",
journal = "Journal of Pediatric and Adolescent Gynecology",
issn = "1083-3188",
publisher = "Elsevier Inc.",
number = "6",
}