Abstract
We have previously described our data collected after administration of gonadotropin releasing hormone-agonist (GnRH-a) to delay sexual maturation, in premenarchal girls suffering from idiopathic central precocious puberty. 1 We have explained the recurrent episodes of bleeding due to discontinuation of the estrogen support of the proliferative and stable endometrium. The recognition in recent years of the extra-pituitary functions of GnRH-a, the ability of GnRH to stimulate prostaglandin production and the known role of prostaglandins in irregular vaginal bleeding prompted us to seek alternative explanations to our data.We suggest considering a potential clinical use of combination therapies of GnRH agonists and prostanoid receptor antagonists to treat central precocious puberty.
Original language | English |
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Pages (from-to) | 365-367 |
Number of pages | 3 |
Journal | Journal of Pediatric and Adolescent Gynecology |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2011 |
Keywords
- GnRH agonist
- Precocious puberty
- Prostaglandins
- Vaginal bleeding