Insight: Prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist: A proposed mechanism and management plan

Arieh Kauschansky, Raoul Orvieto, Arie Yeshaya, Boris Shterntal, Zvi Naor

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously described our data collected after administration of gonadotropin releasing hormone-agonist (GnRH-a) to delay sexual maturation, in premenarchal girls suffering from idiopathic central precocious puberty. 1 We have explained the recurrent episodes of bleeding due to discontinuation of the estrogen support of the proliferative and stable endometrium. The recognition in recent years of the extra-pituitary functions of GnRH-a, the ability of GnRH to stimulate prostaglandin production and the known role of prostaglandins in irregular vaginal bleeding prompted us to seek alternative explanations to our data.We suggest considering a potential clinical use of combination therapies of GnRH agonists and prostanoid receptor antagonists to treat central precocious puberty.

Original languageEnglish
Pages (from-to)365-367
Number of pages3
JournalJournal of Pediatric and Adolescent Gynecology
Volume24
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • GnRH agonist
  • Precocious puberty
  • Prostaglandins
  • Vaginal bleeding

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