Inositol levels in post mortem brain samples of Alzheimer's patients

Galila Agam, Hady Shimon, Joseph Shapiro, Michael Davidson, Varham Haroutunian

Research output: Contribution to journalArticlepeer-review

Abstract

1. Free inositol levels in occipital and parietal cortex of Alzheimer's Disease (AD) patients were reported to be significantly elevated by 10-35% compared with matched controls, studied by magnetic resonance spectroscopy (MRS) during life. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls. 3. The present study shows non-significant trends of 13% increase in frontal cortex and 5% and 21% decrease in occipital cortex and cerebellum respectively, in post mortem brain specimens of AD patients measured gas chromatographically (GC).

Original languageEnglish
Pages (from-to)1241-1250
Number of pages10
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume22
Issue number8
DOIs
StatePublished - Nov 1998
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Brain
  • Inositol
  • Post mortem

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