Inositol 6 g daily may be effective in depression but not in schizophrenia

Joseph Levine; Mirtha Gonsalves; Izak Babur; Shaul Stier; Avner Elizur; Ora Kofman; R. H. Belmaker

doi:10.1002/hup.470080109

Inositol 6 g daily may be effective in depression but not in schizophrenia

Joseph Levine, Mirtha Gonsalves, Izak Babur, Shaul Stier, Avner Elizur, Ora Kofman, R. H. Belmaker^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11 depressed patients resistant to previous treatment led to major improvement in nine patients. The enzyme synthesizing inositol has been reported to be elevated in schizophrenia, suggesting an attempted compensation for possible inositol deficiency. A controlled double‐blind crossover trial in 10 chronic schizophrenic patients of 6 g/day of inositol for 30 days did not reveal any benefit.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	Human Psychopharmacology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/hup.470080109
State	Published - 1993

Keywords

Inositol
depression
schizophrenia

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10.1002/hup.470080109

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abstract = "Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11 depressed patients resistant to previous treatment led to major improvement in nine patients. The enzyme synthesizing inositol has been reported to be elevated in schizophrenia, suggesting an attempted compensation for possible inositol deficiency. A controlled double‐blind crossover trial in 10 chronic schizophrenic patients of 6 g/day of inositol for 30 days did not reveal any benefit.",

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AU - Elizur, Avner

AU - Kofman, Ora

AU - Belmaker, R. H.

PY - 1993

Y1 - 1993

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AB - Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11 depressed patients resistant to previous treatment led to major improvement in nine patients. The enzyme synthesizing inositol has been reported to be elevated in schizophrenia, suggesting an attempted compensation for possible inositol deficiency. A controlled double‐blind crossover trial in 10 chronic schizophrenic patients of 6 g/day of inositol for 30 days did not reveal any benefit.

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KW - schizophrenia

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Inositol 6 g daily may be effective in depression but not in schizophrenia

Abstract

Keywords

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