Inorganic lead enhances cytokine-induced elevation of matrix metalloproteinase MMP-9 expression in glial cells

Nitza Lahat*, Sarah Shapiro, Paul Froom, Estela Kristal-Boneh, Michael Inspector, Ariel Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Inorganic lead (Pb) is a ubiquitous environmental contaminant that produces a variety of deleterious effects in the central nervous system (CNS). Matrix metalloproteinases (MMPs), specifically MMP-9, induced by inflammatory cytokines, are increasingly being implicated in CNS pathology. The present study demonstrates that low concentrations of either pro-inflammatory cytokines (TNF-α and IL-1β) or Pb did not influence the MMP-9 expression in a glial cell line (C6) when added separately. However, combined administration of Pb and cytokines induced a marked synergized elevation of MMP-9 expression in spite of a reduction in the number of glial cells. These results demonstrate a possible new mechanism by which Pb may induce neuropathological processes.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Neuroimmunology
Volume132
Issue number1-2
DOIs
StatePublished - Nov 2002

Funding

FundersFunder number
Rappaport Institute for Research in Medical Sciences
Technion-Israel Institute of Technology

    Keywords

    • Astrocytes
    • Inorganic lead
    • Matrix metalloproteinase
    • Neurotoxicity

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